April 15, 2005  


April 26 Public Lecture: Smarter Drug Design

By Linda DuShane White & Heather Rock Woods

Clyde Smith (SSRL) will speak on ‘Smarter Drugs—How Protein Crystallography Revolutionizes Drug Design’ for the SLAC Public Lecture on Tuesday, April 26, at 7:30 p.m. in Panofsky Auditorium.

Clyde Smith
Photo by Amanda Prado

According to Smith, protein crystallography allows scientists to design drugs in a much more efficient way than the standard methods traditionally used by large drug companies, which can cost close to a billion dollars and take 10 to 15 years.

“A lot of the work can be compressed down,” Smith said. Protein crystallography enables researchers to learn the structure of molecules involved in disease and health. Seeing the loops, folds and placement of atoms in anything from a virus to a healthy cell membrane gives important information about how these things work—and how to encourage, sidestep or stop their functions. Drug design can be much faster when the relationship between structure and function tells you what area of a molecule to target.

Smith will use a timeline to illustrate the traditional methods of drug development and the new ways it can be done now. “It is very exciting work. There have been some failures, but many successes too.”
A new drug to combat the flu was developed in a year or so. Smith will tell us how. He will also highlight drugs developed to combat HIV, Tuberculosis, hypertension and Anthrax.

After two decades of research in New Zealand, Smith came to SSRL in late 2003 to do structural biology with SSRL’s high-intensity x-rays and is developing experiments for the x-ray free electron laser being built at SLAC.

Born and educated in New Zealand, his research studies have included how bacteria become resistant to drugs, bacterial cell wall biosynthesis, antibiotic resistance and viral DNA packaging. He won the Applied Biosystems/NZSBMB Award in 2003.

The public lecture is free and no reservations are necessary. A photo ID is required to enter the Lab.

For more information on the Public Lecture Series, see:


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Last update Thursday May 05, 2005 by Topher White